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. 2021 Feb 2;12(1):25–40. doi: 10.1016/j.jcmgh.2021.01.011

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

In acute-on-chronic liver failure patients, 95% show serum bile acids activating TGR5. (A) Proportion of subjects with serum bile acids activating TGR5. (B) TGR5 activity induced by serum bile acid profiles. Data are means ± SD. One-way repeated-measures analysis of variance with Bonferroni correction. ∗P < .05 compared with HC, ∗∗∗P < .001 compared with HC, and ^###P < .001 compared with ACLF. (C) Correlation between serum bile acid concentration and TGR5 activity induced by serum bile acids, Spearman correlation rank test. ACLF, acute-on-chronic liver failure; ALF, acute liver failure; HC, healthy control; LGF, liver graft failure.