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TGR5 activation by primary bile acids. TGR5 activity was measured for each bile acid at increasing concentrations. The concentration that was required to achieve the half-maximal effect of TLCA was calculated. CA, cholic acid; CDCA, chenodeoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; TCA, taurocholic acid; TCDCA, taurocholic acid.
