Table 2.
Characteristics of Liver Failure Patients With and Without TGR5-Activating Serum Bile Acids
| Characteristics | TGR5-activating serum bile acids? |
P | |
|---|---|---|---|
| Yes |
No |
||
| n = 22 | n = 11 | ||
| Age, y | 55 ± 12 | 56 ± 13 | NS |
| Male sex, % (n) | 50 (11) | 64 (7) | NS |
| Etiology of liver failure, % (n) | |||
| Acute-on-chronic | 81.8 (18) | 9.1 (1) | |
| Alcoholic cirrhosis | 50.0 (11) | ||
| Viral cirrhosis | 4.5 (1) | ||
| Viral and alcoholic cirrhosis | 4.5 (1) | ||
| Cryptogenic cirrhosis | 9.0 (2) | 4.5 (1) | |
| Other cirrhosisa | 13.6 (3) | ||
| Acute | 13.6 (3) | 54.5 (6) | |
| Liver graft failure | 4.5 (1) | 36.4 (4) | |
| Hemodialysis, % (n) | 55 (12) | 45 (5) | NS |
| Serum levels | |||
| ALT, U/L | 42 (27–99) | 54 (40–88) | NS |
| AST, U/L | 86 (64–353) | 78 (57–126) | NS |
| AST/ALT | 2.2 (1.4–3.2) | 1.6 (1.3–2.1) | NS |
| ALP, U/L | 118 (79–161) | 147 (70–444) | NS |
| Total bilirubin, μmol/L | 357 ± 120 | 350 ± 81 | NS |
| Albumin, g/L | 18 (17–25) | 19 (16–23) | NS |
| Bile acid serum parameter | |||
| Total serum bile acids, μmol/L | 285 (166–476) | 72 (46–96) | <.001 |
| TGR5 activity by bile acids, % | 48.4 ± 12.4 | 15.6 ± 7.7 | <.001 |
NOTE. Values are means ± SD or median with 95% CI.
ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase.
a
Other causes of cirrhosis included the following: 1 patient with primary sclerosing cholangitis, 1 patient with primary biliary cholangitis, and 1 patient with Alagille–Watson syndrome.