Table 3.
Serum Bile Acid Profile of Healthy Controls vs Liver Failure Patients With TGR5-Activating Serum Bile Acids
| Bile acid profile, μmol/L | Healthy controls (n = 22) | Patients (n = 22) | P | TGR5 activity,a% |
|---|---|---|---|---|
| Primary bile acids | ||||
| Cholic acid | 0.3 ± 0.5 | 0.1 ± 0.1 | NS | 0.0 |
| Taurocholic acid | 0.0 ± 0.1 | 7.8 ± 9.9 | NS | 0.9 |
| Glycocholic acid | 0.2 ± 0.2 | 15.4 ± 15.8 | < .01 | 1.6 |
| Chenodeoxycholic acid | 0.4 ± 0.7 | 0.2 ± 0.2 | NS | 0.1 |
| Taurochenodeoxycholic acid | 0.1 ± 0.1 | 23.7 ± 12.3 | < .001 | 16.5 |
| Glycochenodeoxycholic acid | 0.9 ± 0.6 | 29.2 ± 21.1 | < .001 | 17.4 |
| Secondary bile acids | ||||
| Lithocholic acid | 0.0 ± 0.0 | 0.0 ± 0.0 | NS | 0 |
| Taurolithocholic acid | 0.0 ± 0.0 | 0.0 ± 0.1 | NS | 0 |
| Deoxycholic acid | 0.5 ± 0.8 | 0.0 ± 0.0 | NS | 0 |
| Taurodeoxycholic acid | 0.1 ± 0.1 | 0.2 ± 0.8 | NS | 0.4 |
| Glycodeoxycholic acid | 0.3 ± 0.3 | 0.4 ± 1.3 | NS | 0.6 |
| Tertiary bile acids | ||||
| Ursodeoxycholic acid | 0.1 ± 0.3 | 6.0 ± 6.4 | NS | 1.0 |
| Tauroursodeoxycholic acid | 0.0 ± 0.0 | 21.0 ± 14.3 | < .001 | 3.2 |
| Glycoursodeoxycholic acid | 0.1 ± 0.2 | 81.2 ± 56.9 | < .001 | 8.3 |
| Total | 50.0 |
NOTE. Values are means ± SD, 1-way analysis of variance with Bonferroni correction.
a
TGR5 activity caused by single serum bile acids from patients; calculated according to the formula shown in Figure 6C (eg, glycocholic acid in serum from patients was increased significantly and caused a TGR5 activity of 1.6%).