Skip to main content
. 2021 Apr 17;2(2):100450. doi: 10.1016/j.xpro.2021.100450

Figure 7.

Figure 7

Local and organizational structure preservation analysis for human colonic mucosa dataset

(A) t-SNE embedding highlighting tuft cell cluster.

(B) Local structure preservation correlation plot for tuft cell cluster, comparing t-SNE coordinates (latent space) to 50-component PCA (native space).

(C) t-SNE embedding highlighting secretory lineage from stem cells (cluster 3) to goblet cells (cluster 8) and mature goblet cells (clusters 4 and 12).

(D) Structure preservation correlation plot showing distances between stem and mature cell lineage clusters.

Indicated with red arrows in (B and G) and (D and I) are latent space distance distributions which differ between t-SNE and UMAP.

(E) t-SNE embedding with minimum spanning tree (MST) drawn between Leiden cluster centroids. Red edges represent those not present in native (PCA) space.

(F–J) Same as in (A–E), for UMAP embedding.