Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 16;12(1):1–24. doi: 10.1016/j.jcmgh.2020.12.010

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Presence of enteric neurons within the aganglionic gut of Wnt1^Cre;R26^tdTom;Ednrb^-/-mice. (A and A’) Whole-mount views of the gut from a P0 Wnt1^Cre;R26^tdTom;Ednrb^-/- mouse, showing an innervated segment within the aganglionic intestine. Arrowheads indicate the proximal wavefront of eNCCs and arrows indicate pioneer pelvic ganglion-arising axons within the distal hindgut. (B) Representative magnified view of the innervated segment, showing mNCC-derived neurons (TUJ1⁺/PHOX2B⁺/SOX10^-; white arrowheads), mNCC-derived glia (TUJ1^-/PHOX2B^-/SOX10⁺; green arrowheads), and NCCs (TUJ1^-/PHOX2B⁺/SOX10⁺; red arrowheads). (C) Incidence of different types of aganglionosis within the guts of Ednrb^-/- and Wnt1^Cre;R26^tdTom;Ednrb^-/- mice. CC, cecum; DCA, distal colonic aganglionosis; DCA with SS, skip segment within DCA sample SS, skip segment; TCA, total colonic aganglionosis; TCA with SS, skip segment within TCA sample.