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. 2020 Dec 16;12(1):1–24. doi: 10.1016/j.jcmgh.2020.12.010

Figure 4.

Figure 4

A subset of vNCCs migrate along the mesentery at E10.5. (A) Representative image of E10.5 vGlut2Cre;R26tdTom embryos with PHOX2B and TUJ1 staining. (A’) Magnified view of the boxed area in panel A. Arrows indicate pioneer vagus axons (TOM+/TUJ1+). Dotted lines mark the sites of the sections shown in panels B–E, and the presumptive margins of the gut, respectively. Note the presence of mNCCs (arrowheads) within the mesentery. (B–E) Transverse sections showing the distribution of vNCCs within the dorsal mesentery of the (B and C) esophagus, (D) stomach, and (E) duodenum. Note the presence of fewer PHOX2B+ cells in the antimesenteric side of the gut. Dotted lines indicate the presumptive margins of the gut. D, duodenum; DAPI, 4′,6-diamidino-2-phenylindole; ES, esophagus; SCG, sympathetic chain ganglion; ST, stomach.