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. 2021 Apr 15;11:665246. doi: 10.3389/fonc.2021.665246

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Copyright © 2021 Fang, Ding, Ding, Li, Liu, Lv and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The formation modes of circRNA. (A, B) CircRNAs with intronic complementary sequence (ICS) of pre-mRNA can make the distal intron splicing sites closer in space to promote reverse splicing and ICS pair-driven cyclization. (C, D) CircRNAs with double-stranded RNA binding domain (dsRBD) can bind and pair with ICS to make the splice site closer, as well as facilitate reverse splicing to increase circRNAs formation. (E) In the exon skipping event, the exon lariat formed by the covalently combined splice acceptor and splice donor provided by the exon. (F) Intronic lariat-driven cyclization was caused by intron removal during the pre-mRNA splicing process.