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. 2021 Apr 15;11:665246. doi: 10.3389/fonc.2021.665246

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Copyright © 2021 Fang, Ding, Ding, Li, Liu, Lv and Shi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The mechanism of circRNA in gastrointestinal tumors. (A) CircRNAs can act as miRNA sponge or decoys as well as regulate the function of downstream mRNA. (B) CircRNAs with RNA binding protein (RBP) binding motifs may sponge or decoy the RBPs and regulate their functions. (C) A few circRNAs can combine with several RBPs and function as protein scaffolds to affect the tumor progressions. (D) Some circRNAs are involved in gene transcription regulation by recruiting the transcription regulators to influence promoters. (E, F) CircRNAs containing internal ribosome entry site (IRES) elements and AUG sites may act as templates as well as be translated.