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. 2021 Apr 15;13:643809. doi: 10.3389/fnagi.2021.643809

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Copyright © 2021 Boa Sorte Silva, Petrella, Christopher, Marriott, Gill, Owen and Petrella.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Baseline and follow-up means for time to exhaustion during exercise stress tests (bar plots, group mean and 95% CI) and estimated mean change from baseline to 6 months (scatterplots, estimated mean change and 95% CI). (A,B) Display changes for the entire sample, while (C,D) display changes stratified by males and females. *, significant changes over time; #, significant subgroup changes over time at adjusted significance threshold (p ≤ 0.005), with improvements in females within the MCT group [estimated mean change (95% CI): 1.61 min (0.9 to 2.33), p = 0.00003] and males within the HIIT group [1.47 min, (0.87 to 2.07), p = 0.000006]. See Supplementary Table 3 for further details. HIIT, high-intensity interval training; MCT, moderate-intensity continuous training.