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. 2021 Apr 15;12:621858. doi: 10.3389/fimmu.2021.621858

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Copyright © 2021 Shen, Chen and Wei

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) In March 2019, the patient was diagnosed as type B3 thymoma with pleural dissemination, and her clinical stage was Masaoka stage IVA. (B) In May 2019, the evaluation of tumor response to chemotherapy is SD (RECIST). (C) In August 2019, the tumor responded to pembrolizumab. (D) In October 2019, a near complete response was achieved following a dose of pembrolizumab. (E) In March 2020, the disease progressed and 100 mg of pembrolizumab was administered. (F) The patient responded to 100 mg pembrolizumab with partial regression. (G) In September 2020, progression of the disease was found. (H) The patient responded to 100 mg pembrolizumab again.