Table 2.
Demographics and clinical data of the 198 patients treated with curative surgery.
| Parameter | Involvement of mucosal boundary areas | P-value* | |
|---|---|---|---|
| Present (n = 65) | Absent (n = 133) | ||
| Sex | |||
| Male Female |
16 (24.6%) 49 (75.4%) |
105 (78.9%) 28 (21.1%) |
<0.0001 |
| Age (year) | |||
| Mean ± SD | 69.7 ± 10.3 | 73.5 ± 9.12 | 0.0091 |
| Tumor site | |||
| Perianal area Other areas |
12 (18.5%) 53 (81.5%) |
5 (3.8%) 128 (96.2%) |
0.0018 |
| Primary lesion size (cm2) | |||
| <25 ≥25 |
26 (40.0%) 39 (60.0%) |
64 (48.1%) 69 (51.9%) |
0.29 |
| Tumor thickness (mm) | |||
| In situ ≤4 >4 |
30 (46.2%) 26 (40.0%) 9 (13.8%) |
72 (54.1%) 54 (40.6%) 7 (5.3%) |
0.12† |
| Lymphovascular invasion | |||
| Present Absent |
7 (10.8%) 58 (89.2%) |
4 (3.0%) 129 (97.0%) |
0.042 |
| Regional LN metastasis | |||
| Present Absent |
13 (20.0%) 52 (80.0%) |
4 (3.0%) 129 (97.0%) |
0.0002 |
| Number of regional LN metastases | |||
| 1 2 or more |
4 (30.8%) 9 (69.2%) |
3 (75.0%) 1 (25.0%) |
0.25 |
| TNM stage | |||
| 0 I II IIIa IIIb |
30 (46.2%) 20 (30.8%) 2 (3.1%) 4 (6.2%) 9 (13.9%) |
72 (54.1%) 50 (37.6%) 7 (5.3%) 3 (2.3%) 1 (0.8%) |
0.0014 |
| Local recurrence | |||
| Present Absent |
12 (18.5%) 53 (71.5%) |
0 (0.0%) 133 (100.0%) |
<0.0001 |
| Follow-up period (month) | |||
| Mean ± SD Median (range) |
82.8 ± 64.0 58.2 (7.2–256.5) |
83.7 ± 57.4 78.9 (2.0–264.7) |
0.73 |
Significant values are shown in boldface.
*Mann-Whitney U tests were used for continuous variables, and χ2 or Fisher’s exact tests were used for categorical variables.
†In situ vs. ≤ 4 mm, p = 0.65; in situ vs. > 4 mm, p = 0.040; ≤ 4 mm vs. > 4 mm, p = 0.077.
SD, standard deviation; LN, lymph node; TNM, tumor, node, metastasis.