TABLE 1.
Effects of TLB on the mean lifespan of C. elegans.
| Genotype | Mean lifespan ±SEM (days) | Chang (%) | Number of C. elegans (N) | p Value | |
|---|---|---|---|---|---|
| Untreated | Treated | ||||
| N2 | 22.2 ± 0.7 | 23.9 ± 0.7 a | 7.7 | 183 | 0.023 |
| 24.9 ± 0.6 b | 11.7 | 180 | 0.009 | ||
| 27.2 ± 0.6 c | 22.1 | 181 | <0.001 | ||
| N2 (oxidative stress) | 9.9 ± 0.3 | 12.0 ± 0.4 | 22.1 | 194 | <0.001 |
| N2 (heat stress) | 10.0 ± 0.5 | 11.5 ± 0.5 | 14.2 | 189 | 0.035 |
| skn-1 (zu67) IV | 20.2 ± 0.5 | 20.8 ± 0.5 | 2.9 | 203 | 0.403 |
| daf-16 (mu86) | 19.5 ± 0.3 | 20.1 ± 0.3 | 3.1 | 200 | 0.112 |
| sir-2.3 (ok444) X | 19.3 ± 0.6 | 20.9 ± 0.7 | 8.2 | 177 | 0.052 |
| sod-3 (gk235) X | 18.2 ± 0.5 | 17.8 ± 0.4 | -−.4 | 172 | 0.437 |
| sod-2 (ok1030) I | 19.6 ± 0.6 | 19.8 ± 0.5 | 1.3 | 176 | 0.918 |
| gst-4&msp-38 (ok2358) IV | 21.9 ± 0.4 | 20.5 ± 0.5 | −6.5 | 178 | 0.120 |
| eat-2 (ad1116) II | 22.6 ± 0.6 | 24.7 ± 0.6 | 9.3 | 169 | 0.008 |
a
Unless otherwise specified, TLB-treated concentration was 250 μM.
b
TLB-treated concentration was 62.5 μM.
c
TLB-treated concentration was 125 μM.