TABLE 5.
Summary of bacterial response of vancomycin and AUC0–24/MIC by the most common infection sites and bacteria.
| Bacterial classification | N | Bacterial eradication | AUC0–24/MIC | ||
|---|---|---|---|---|---|
| n (%) | P value* | Median (IQR) | P value** | ||
| Bloodstream | 1.0000 | 0.0039 | |||
| SA | 8 | 8 (100.0) | 315.0 (215.5, 367.0) | ||
| CoNS | 32 | 31 (96.9) | 187.0 (152.0, 250.5) | ||
| Enterococcus | 7 | 7 (100.0) | 214.0 (184.0, 528.0) | ||
| Other | 4 | 4 (100.0) | 553.5 (470.0, 746.0) | ||
| Pulmonary | 1.0000 | 0.0382 | |||
| SA | 24 | 23 (95.8) | 220.5 (201.0, 301.0) | ||
| CoNS | 1 | 1 (100.0) | 186.0 (186.0, 186.0) | ||
| Enterococcus | 1 | 1 (100.0) | 69.0 (69.0, 69.0) | ||
| Other | 3 | 3 (100.0) | 833.0 (660.0, 1060.0) | ||
| Urinary tract | NA | 0.0322 | |||
| SA | 2 | 2 (100.0) | 138.0 (137.0, 139.0) | ||
| CoNS | 2 | 2 (100.0) | 261.5 (233.0, 290.0) | ||
| Enterococcus | 11 | 11 (100.0) | 179.0 (145.0, 286.0) | ||
| Central Nerve System | 0.0909 | 0.2012 | |||
| SA | 1 | 0 (0.0) | 200.0 (200.0, 200.0) | ||
| CoNS | 2 | 2 (100.0) | 276.0 (166.0, 386.0) | ||
| Enterococcus | 2 | 2 (100.0) | 512.0 (178.0, 846.0) | ||
| Other | 6 | 6 (100.0) | 1082.5 (820.0, 1313.0) | ||
| Endocarditis | NA | 0.7633 | |||
| SA | 1 | 1 (100.0) | 195.0 (195.0, 195.0) | ||
| CoNS | 1 | 1 (100.0) | 240.0 (240.0, 240.0) | ||
| Enterococcus | 1 | 1 (100.0) | 196.0 (196.0, 196.0) | ||
| Other | 3 | 3 (100.0) | 462.0 (188.0, 478.0) | ||
*
Fishers’ Exact test.
**
Maximum likelihood ratio test.
SA: Staphylococcus aureus; CoNS: Coagulase-Negative Staphylococcus; AUC0–24/MIC: 0–24 h area under the curve to MIC ratio; IQR: interquartile range; NA: not applicable.