TABLE 6.

Population PK model predicted probability of target attainment (PTA) of vancomycin in pediatric patients at different ages under different dosing regimens and different target values.

AUC0–24/MIC target value	Age period	Dose regimen	MIC (mg/L)
		(q6h, q8h or q12h) (mg/kg/day)	0.125	0.25	0.5	1	2
200	0–3m	40	100	100	98.6	66.7	17.4
		50	100	100	100	81.9	31.9
		60	100	100	100	89.9	44.2
		70	100	100	100	94.2	57.2
		80	100	100	100	98.6	66.7
	3m–12y	40	100	100	100	76.7	26.1
		50	100	100	100	88.9	43.3
		60	100	100	100	96.1	56.7
		70	100	100	100	99.4	65.6
		80	100	100	100	100	76.7
	12y -17y	40	100	100	100	91.0	46.5
		50	100	100	100	99.0	66.0
		60	100	100	100	100	79.5
		70	100	100	100	100	85.5
		80	100	100	100	100	91.0
250	0–3m	40	100	100	92.0	50.7	9.4
		50	100	100	98.6	66.7	17.4
		60	100	100	100	81.2	30.4
		70	100	100	100	87.7	39.1
		80	100	100	100	92.0	50.7
	3m–12y	40	100	100	97.8	61.1	16.7
		50	100	100	100	76.7	26.1
		60	100	100	100	86.7	38.9
		70	100	100	100	92.2	50.6
		80	100	100	100	97.8	61.1
	12y -17y	40	100	100	100	83.0	26.5
		50	100	100	100	91.0	46.5
		60	100	100	100	97.0	61.0
		70	100	100	100	100	75.0
		80	100	100	100	100	83.0
300	0–3m	40	100	100	84.1	35.5	3.6
		50	100	100	93.5	54.3	10.1
		60	100	100	98.6	66.7	17.4
		70	100	100	100	79.0	26.8
		80	100	100	100	84.1	35.5
	3m–12y	40	100	100	90.6	47.2	8.9
		50	100	100	98.3	62.8	18.3
		60	100	100	100	76.7	26.1
		70	100	100	100	85.0	36.1
		80	100	100	100	90.6	47.2
	12y–17y	40	100	100	99.5	70.5	17.5
		50	100	100	100	83.5	29.5
		60	100	100	100	91.0	46.5
		70	100	100	100	96.5	58.5
		80	100	100	100	99.5	70.5
400	0–3m	40	100	98.6	66.7	17.4	0.7
		50	100	100	81.9	31.9	2.9
		60	100	100	89.9	44.2	5.8
		70	100	100	94.2	57.2	10.9
		80	100	100	98.6	66.7	17.4
	3m–12y	40	100	100	76.7	26.1	3.3
		50	100	100	88.9	43.3	7.8
		60	100	100	96.1	56.7	14.4
		70	100	100	99.4	65.6	19.4
		80	100	100	100	76.7	26.1
	12y–17y	40	100	100	91.0	46.5	5.5
		50	100	100	99.0	66.0	14.0
		60	100	100	100	79.5	23.5
		70	100	100	100	85.5	34.0
		80	100	100	100	91.0	46.5

q6 h: every 6 h; q8h: every 8 h; q12 h: every 12 h.

Bold text: target attainment above 90%.