TABLE 1.
K a and P app values of some anthraquinone compounds absorbed in different intestines and colons of rats.
Duodenum | Jejunum | Ileum | Colons | References | |||||
K am (×10−4/s) | P app (×10−5 cm/s) | K a (×10−4/s) | P app (×10−5 cm/s) | K a (×10−4/s) | P app (×10−5 cm/s) | K a (×10−4/s) | P app (×10−5 cm/s) | ||
AE | 5.43–16.07 | 7.65–10.68 | 4.88–13.03 | 6.29–9.83 | 2.23–8.63 | 3.45–5.90 | 3.88–12.17 | 5.12–7.9 | (Wang et al., 2011a; Wang et al., 2011b; Qiu et al., 2011) |
CH | 19.02 | 13.77 | 15.15 | 12.88 | 10.80 | 10.27 | 18.17 | 15.22 | |
EM | 15.55 | 10.18 | 11.45 | 7.98 | 8.38 | 5.65 | 12.45 | 8.05 | |
PH | 10.08 | 5.53 | 6.38 | 3.83 | 6.22 | 4.00 | 16.12 | 12.42 | |
RH | 6.96–10.68 | 6.15–8.91 | 5.70–11.13 | 7.95–8.22 | 4.79–6.27 | 4.17–6.59 | 5.18–6.55 | 3.85–8.92 |
K a: absorption rate constant; P app: apparent absorption coefficient; AE: aloe-emodin; CH: chrysophanol; EM: emodin; PH: physcion; RH: rhein. The number of male and female rats in the studies was equal.