TABLE 3.

Distribution of anthraquinones in various tissues and organs.

Components	Species/biomatrix	Administration routines	Administration dosage	Distribution	References
Aloe-emodin	KM mouse	i.g.	300 mg/kg (rhubarb extract)	Intestines, stomach, kidney, lung, muscle, liver, heart, fat, brain, plasma, spleen	(Wang et al., 2020)
Aloe-emodin	KM mouse	i.g.	52.2 mg/kg, 26.1 mg/kg, 13.05 mg/kg	Intestines, heart, lung, liver, kidney, brain, stomach, spleen, muscle, fat, plasma	(Li and Feng, 2018)
Chrysophanol	KM mouse	i.g.	300 mg/kg (rhubarb extract)	Stomach, intestines, liver, spleen, kidney, fat, lung, plasma, muscle, heart, brain	(Wang et al., 2020)
Chrysophanol	New Zealand rabbits	i.v.	15 mg/kg	Heart, lung, liver, kidney, brain	(Tan et al., 2013)
Chrysophanol	SD rats	i.g.	15 mg/kg	Heart, kidney, spleen, liver, lung, brain	(Chen et al., 2014)
Chrysophanol	KM mouse	i.v.	10 mg/kg	Blood, heart, kidney, spleen, liver, lung, brain	(Zhu et al., 2012)
Emodin	KM mouse	i.v.	(5.45 μg,13.7 nmol) 0.1 ml	Blood, lung, kidney, stomach, thyroid, liver, bone, small intestines, skin, heart, spleen, mucle, brain	(Du et al., 2014)
Emodin	KM mouse	i.g.	300 mg/kg (rhubarb extract)	Stomach, intestines, liver, kidney, lung, spleen, plasma, fat, heart, muscle, brain	(Wang et al., 2020)
Rhein	KM mouse	i.g.	300 mg/kg (rhubarb extract)	Liver, stomach, intestines, plasma, spleen, kidney, lung, heart, fat, muscle, brain	(Wang et al., 2020)
Rhein	SD rats	i.g.	2.0 g/kg of rheum palmatum L. decoction	Kidney, liver, lung	(Shia et al., 2011b)
Physcion	KM mouse	i.g.	300 mg/kg (rhubarb extract)	Intestines, stomach, liver, lung, spleen, heart, plasma, muscle, fat, brain, kidney	(Wang et al., 2020)