Fig. 1.

Overview of study design. A flowchart of the study design divided in two boxes; 1) manual segmentation protocol and 2) quantitative performance metrics. The manual segmentation protocol was used to create three datasets; quantitative performance metrics were used to assess spatial (JI, DSC and CIgen) and volumetric agreement (ICC). Abbreviations: CIgen = generalized conformity index; ICC = intraclass correlations; DSC = Dice Similarity Coefficient, JI = Jaccard index; N = number of subjects.