Fig. 2.

Rimonabant improves dyslipidemia as related to increased triglyceride (TG)-rich lipoprotein turnover. Female APOE∗3-Leiden.CETP mice were fed a Western-type diet with or without rimonabant for 20 weeks. A: Body weight, (B) food intake, as well as plasma levels of (C) triglycerides, (D) total cholesterol, (E) non-HDL-C, and (F) HDL-C were monitored throughout the intervention period. Plasma clearance and organ uptake of (G–I) TG-derived ³H-labeled FAs and (J–L) ¹⁴C-labeled cholesteryl ester from recombinant TG-rich lipoproteins were determined and expressed per gram gonadal WAT (gWAT) and subcutaneous WAT (sWAT), muscle, interscapular brown adipose tissue (iBAT), and subscapular brown adipose tissue (sBAT), liver, perivascular adipose tissue (pVAT), and spleen. Liver samples were collected to assess (M) relative mRNA expression levels of angiopoietin-like protein (Angptl) 3, 4, and 8 and of Lpl. Data are presented as mean ± SEM and individual data points. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.