Fig. 1.

Domain architecture and N-end structure of ANP32B. (A) Schematic representation of ANP32B domain organization. The N-end structured domain of ANP32B is colored in blue, whereas the histone chaperone LCAR is represented in yellow. The four LRRs are colored in red. ANP32B Nuclear Localization Signal (NLS) is represented in orange and the histone chaperone Nuclear Export Signal (NES) is marked on the image. ANP32B Thr244 residue is represented in grey. (B) Ribbon representation of ANP32B (PDB: 2ELL [12]) N-terminal domain following the color scheme described in A. ANP32B structure is rotated 90° around the horizontal axes in each view. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)