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. 2021 Apr 20;45(6):110. doi: 10.3892/or.2021.8061

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Vanillin combined with 5-Fu induces cell apoptosis in CRC cells. CRC cell lines, HT-29/NC, HT-29/shNNMT, SW480/NC and SW480/NNMT, were treated with vanillin and/or 5-Fu (40 mg/l for HT-29 cells, 20 mg/l for SW480 cells) for 48 h. The untreated groups were displayed as blank groups. (A and B) Cell apoptosis was analyzed by flow cytometry and is displayed as histograms in HT-29/NC and HT-29/shNNMT (A) and SW480/NC and SW480/NNMT (B) cell lines. Data are represented as means ± SD, n=3; *P<0.05, **P<0.01, ***P<0.001. Van, vanillin; CRC, colorectal cancer; NNMT, nicotinamide N-methyltransferase; 5-Fu, 5-fluorouracil.