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. 2021 Apr 20;45(6):110. doi: 10.3892/or.2021.8061

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Inhibition of the ASK1-p38 MAPK pathway reverses the increased apoptosis induced by vanillin. CRC cell lines, HT-29/NC, HT-29/shNNMT, SW480/NC and SW480/NNMT, were treated with vanillin and/or SB203580 for 48 h. The untreated groups were displayed as blank groups. (A and B) Cell apoptosis was analyzed by flow cytometry in HT-29/NC and HT-29/shNNMT (A) and SW480/NC and SW480/NNMT (B) cell lines. (C and D) Cell apoptosis was displayed as a histogram in HT-29/NC and HT-29/shNNMT (C) and SW480/NC and SW480/NNMT (D) cell lines. Data are represented as means ± SD, n=3; *P<0.05, **P<0.01. Van, vanillin; SB, SB203580; CRC, colorectal cancer; NNMT, nicotinamide N-methyltransferase; ASK1, apoptosis signal regulating kinase 1.