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. 2021 Apr 20;45(6):110. doi: 10.3892/or.2021.8061

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 8. — Vanillin increases cell apoptosis by inducing mitochondrial damage and ROS production. SW480/NC and SW480/NNMT cell lines were treated with vanillin for 48 h, or pretreated with 10 mM NAC for 2 h followed by treatment with vanillin for 48 h. (A and B) ROS were detected by flow cytometry using the fluorescent probe DCFH-DA and displayed as a histogram. (C and D) Measurement of mitochondrial transmembrane potential by JC-1 fluorescence and displayed as histogram. (E) Cell apoptosis was displayed as a histogram. Data are represented as means ± SD, n=3; *P<0.05, **P<0.01, ***P<0.001. Van, vanillin; NAC, N-acetyl-L-cysteine; ROS, reactive oxygen species.