TABLE 1.
Summary of capillarization and endothelial dysfunction of LSECs in NAFLD animal models.
| Model | Species | Capillarization | Stage | Endothelial dysfunction | Stage | Capillarization Indicator(s) | SEM | AFM | Year | Ref |
|---|---|---|---|---|---|---|---|---|---|---|
| HFD | C57BL/6 mice | Not mentioned | N/A | Yes | Early (4 weeks) | N/A | No | No | 2011 | Tateya et al. (2011) |
| CafD | Wistar kyoto rats | No | Early (1 month) | Yes | Early (1 month) | SE-1, CD31, CD34 | No | No | 2012 | Pasarin et al. (2012) |
| HFD | SD rat | Yes | Probably early (43rd day) | Not mentioned | N/A | No | Yes | No | 2014 | Peng et al. (2014) |
| CDAA | C57BL/6 mice | Yes | Early (1 week) | Not mentioned | N/A | CD31, CD34 | Yes | No | 2015 | Miyao et al. (2015) |
| HFD | C57BL/6 mice | Yes | Late (22 weeks) | Not mentioned | N/A | No | Yes | No | 2015 | Miyao et al. (2015) |
| MCD | C57BL/6 mice | Not mentioned | N/A | Yes | Early (4 weeks) | N/A | No | No | 2015 | Pourhoseini et al. (2015) |
| HFGFD | SD OFA rats | Yes | Early (10 weeks) | Yes | Early (10 weeks) | CD31 | No | No | 2019 | Bravo et al. (2019) |
| HFD | C57BL/6 mice | No | Early (2 weeks) and late (20 weeks) | Not mentioned | N/A | No | Yes | Yes | 2019 | Kus et al. (2019) |
AFM, atomic force microscopy; CafD, cafeteria diet; CDAA, choline-deficient l-amino acid-defined; HFD, high fat diet; HFGFD, high fat glucose-fructose diet; MCD, methionine and choline deficient; N/A, not applicable; SEM, scanning electron microscopy