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N. annulifera venom (NaV) induces systemic complementopathy in the murine model. Serum samples were obtained from mice envenomated, i.p., with a sublethal or lethal NaV dose (n=6/venom dose) and AP (A), LP (B) and CP (C) activity evaluated by functional assays. Data are means ± SEM of six independent experiments. ***p ≤ 0.001 (two-tailed one-way ANOVA, followed by Bonferroni post-test). ### indicates significant difference between the sublethal and lethal venom doses.
