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. 2021 Apr 15;8:674632. doi: 10.3389/fmolb.2021.674632

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Copyright © 2021 Lan, Zheng, Li, Chen, Shen and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of Parkin by the dCas9-KRAB system significantly attenuates H₂O₂-induced mitophagy. (A) Vector map of clustered regularly interspaced palindromic repeat epigenome editing vectors targeting the Parkin gene promotor region. (B) Expression level of Parkin in NP cells. (C,D) Western blot of Parkin, P62, LC3-I, and LC3-II expression in NP cells after Parkin inhibition. (E,F) Representative images of TUNEL staining and quantitative analysis showing NP cells apoptosis after Parkin inhibition. *p < 0.05 vs. control group.