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Schematic representation of chemical probes prepared with a combination of DPAL/DTPC and DEL. A DEL library is functionalized with a general ssDNA linked to a dsDNA barcode. The general strand is hybridized with the capture strand. After covalent labeling of the target protein, the target protein is enriched by affinity enrichment. The unbound probes are washed away and the bound probes are analyzed by DNA sequencing.
