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. 2021 Apr 15;12:621181. doi: 10.3389/fphar.2021.621181

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Copyright © 2021 Ye, Zhou, Jin, Li, Zheng, Huang, Liu, Qin, Liu, Zou and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GYZ synergizes with PTX to suppress the growth of NSCLC cells. (A,B) A549 cells (A) and H1975 cells (B) were treated with paclitaxel (PTX) as the indicated doses in the absence or presence of GYZ (100 μM) for 48 h. Cell growth was evaluated by MTT assay. The combination index (CI) of two drugs was listed. (C,D) A549 cells (C) and H1975 cells (D) were treated with PTX as the indicated doses in the absence or presence of GYZ (100 μM) for 2 weeks. Cell proliferation was performed by colony-formation assay. All data are means ± SD. *p < 0.05, ***p < 0.001.