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. 2021 Apr 15;12:656451. doi: 10.3389/fimmu.2021.656451

Figure 2.

Figure 2

Theoretical viral-human zwitter 9mer peptide frequency and potential association with T1D. (A–H) Number of theoretical viral-human 9mer (non-spliced or cis-spliced) (A) zwitter peptides, (B) zwitter epitope candidates predicted to efficiently bind selected HLA-I complexes, (C) zwitter epitope candidates described in published HLA-I immunopeptidomes, (D) zwitter epitope candidates that showed a positive T cell response in published studies, (E) zwitter epitope candidates derived from T1D-associated antigens, (F) zwitter epitope candidates predicted to efficiently bind selected HLA-I complexes and derived from T1D-associated antigens, (G) zwitter epitope candidates described in published HLA-I immunopeptidomes and derived from T1D-associated antigens, (H) zwitter epitope candidates that may be derived from T1D-associated antigens and showed a positive T cell response in published studies. For the identification of epitope candidates already identified in HLA-I immunopeptidomics or analyzed (with positive outcome) for T cell recognition, we consulted the IEDB database.