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. 2021 Apr 15;12:656451. doi: 10.3389/fimmu.2021.656451

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Copyright © 2021 Mishto, Mansurkhodzhaev, Rodriguez-Calvo and Liepe

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of potentially immunogenic zwitter viral cis-spliced/human non-spliced peptide. Predicted crystal structure of the human IA-2 (a.k.a. PTPRN) and HCMV DNA primase (UL70) and theoretical localization of the viral-human zwitter peptide candidate LLPPLLEHL. This peptide may be generated through peptide hydrolysis from human IA-2 and through peptide splicing from HCMV DNA primase. The zwitter non-spliced peptide candidate IA-2_180-188 [LLPPLLEHL] is depicted in orange. For the zwitter cis-spliced peptide candidate UL70_{856-857/832-838} [LL][PPLLEHL], the two splice-reactants are depicted, too.