Figure 4.

Human pancreatic islets and mTECs’ mRNA expression of antigens potentially carrying HLA-A*02:01-restricted viral-human non-spliced and cis-spliced zwitter peptide candidates. The scatter plots depict the distribution of RPKM of mRNA of human antigens, as measured by Gonzalez-Duque and colleagues (19) in human pancreatic islets and mTECs, that theoretically can carry viral-human zwitter (A) non-spliced and (B) cis-spliced epitope candidates. Scatter plots are divided based on the corresponding theoretical virus origin. In (A) only four out of eight viruses are shown because for four viruses no viral-human non-spliced peptide candidates with the required characteristics were identified. Black dots represent antigens carrying epitope candidates predicted to bind the HLA-A*02:01 allele. Red dots represent antigens carrying epitope candidates predicted to bind the HLA-A*02:01 allele and located in hotspots, according to the IEDB database.