Figure 4. INPP5D expression levels were increased in plaque-associated microglia.
INPP5D was mainly expressed in plaque-associated microglia. INPP5D- and IBA1 (AIF1)-positive microglia cluster around 6E10-positive or X-34-positive plaques in both cortex (A) and subiculum (B) of 8-month-old mice. Analysis of transcriptomic data of sorted microglia from murine brains injected with apoptotic neurons (Krasemann et al) revealed a decreased Inpp5d expression in phagocytic microglia compared to non-phagocytic microglia (C). Scale bar, 100 μm. ****p<0.0001