Table 4.
Susceptibility of MAC to antimicrobial agents determined by the broth dilution method
| Grouping/species | Mycobacterium avium‒intracellulare complex (n = 108) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Antimicrobial agent | Broth dilution range (μg/ml) | MIC50 | MIC90 | Susceptible | Intermediate | Resistant | S (%) | I (%) | R (%) |
| Antimicrobial agents and susceptibility breakpoints (MICs) for testing MACa | |||||||||
| First line | |||||||||
| Clarithromycin | 0.06‒64 | 2 | 4 | ≤ 8 | 16 | ≥ 32 | 95.37 | 0 | 4.63 |
| Amikacin | 1‒64 | 16 | 64 | ≤ 16 | 32 | ≥ 64 | 71.30 | 18.52 | 10.19 |
| Second line | |||||||||
| Linezolid | 1‒64 | 32 | 64 | ≤ 8 | 16 | ≥ 32 | 14.81 | 18.52 | 66.67 |
| Moxifloxacin | 0.12‒8 | 2 | 8 | ≤ 1 | 2 | ≥ 4 | 15.74 | 37.04 | 47.22 |
MAC mycobacterium avium‒intracellulare complex, CLSI Clinical and Laboratory Standards Institute
aCLSI M24, 3rd ed., 2018 (2)