Table 4.
Comparing PAC metrics across categorical phenotypes in Phelan-McDermid Syndrome
| Measure | PAC median | Mann–Whitney U | P value |
|---|---|---|---|
| z-MI | – | – | – |
| Sex | – | – | – |
| Female | 2.99 (1.19, 9.83) | 2.16 | .031 |
| Male | 0.836 (0.512, 1.485) | – | – |
| ASD diagnosis | – | – | – |
| Yes | 1.45 (0.337, 3.73) | -.712 | .501 |
| No | 1.60 (0.907, 6.71) | – | – |
| SHANK3 | – | – | – |
| Deletion | 1.22 (0.559, 4.98) | − .723 | .497 |
| Mutation | 1.59 (1.23, 9.63) | – | – |
| Seizure history | – | – | – |
| Yes | 1.84 (.086, 9.50) | .371 | .748 |
| No | 1.23 (.626, 4.35) | – | – |
| Phase bias * 104 | – | – | – |
| Sex | – | – | – |
| Female | 5.00 (2.29, 15.7) | 1.00 | .336 |
| Male | 3.67 (− 0.007, 5.17) | – | – |
| ASD diagnosis | – | – | – |
| Yes | 4.28 (2.88, 15.5) | .876 | .403 |
| No | 3.33 (.534, 7.85) | – | – |
| SHANK3 | – | – | – |
| Deletion | 4.14 (0.210, 15.7) | .145 | .910 |
| Mutation | 4.04 (0.751, 7.57) | – | – |
| Seizure history | – | – | – |
| Yes | 7.99 (− 1.85, 18.5) | .889 | .409 |
| No | 3.84 (1.42, 6.71) | – | – |
Median values (25th and 75th percentile values in parentheses) are presented for each category. All tests performed using a Mann–Whitney U test. A Benjamini–Hochberg correction was applied to ln(z-MI) and phase bias comparisons separately. * indicates significance (FDR = .1)