Table 1.

Eligibility criteria at the community- and individual-levels for the AVENIR mortality and resistance Stage I trial in Niger

Trial	Level	Eligibility Criteria
Mortality	Community	• Location in Dosso or Tahoua region • Population between 250 and 2499a • Distance > 5 km from district headquarters town • Not designated as a “quartier” on national census • Accessible and safe for study team • Verbal consent from community leader(s)
	Individual	• Primary residence in a study community • Age 1–59 months • Weight ≥ 3.0 • No known allergy to macrolides • Verbal consent of guardian for study participation
Resistance	Community	• Location in Dosso • Accessible and safe for study team • Randomly selected • Not included in MORDOR trials • Verbal consent of community leader(s)
	Individual	• Primary residence in a selected study community • 1–59 months old, 7–12 years old or guardian of child eligible for treatment • Randomly selected from census • Verbal consent from guardian

^a Population size as estimated from the most recent national census or projections