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. 2021 Apr 15;12:621845. doi: 10.3389/fendo.2021.621845

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Copyright © 2021 Liu, Du, Gan, Bao, Feng and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical implication of CD3⁺CD4⁺/CD3⁺CD8⁺ ratio in RPL patients with IR. (A) RPL women with decreased CD3⁺CD4⁺/CD3⁺CD8⁺ ratio had significantly higher levels of DI30 and DI120. The increase in the ratio of CD3⁺CD4⁺/CD3⁺CD8⁺ was marked associated with low (B) DI30 and (C) DI120 levels. ROC curve analysis for CD3⁺CD4⁺/CD3⁺CD8⁺ ratio and DI30 (D), and DI120 (E). Data is presented as mean ± standard deviation. DI, disposition index, representing adjusted insulin sensitivity according to HOMA-IR.