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. Author manuscript; available in PMC: 2021 Apr 29.
Published in final edited form as: Gene. 2018 Feb 20;655:1–12. doi: 10.1016/j.gene.2018.02.048

Figure 2: Pharmacological Modulation of the circadian clock reverses pain hypersensitivity.

Figure 2:

(Fig. 2A) Both groups had circadian disruption for 12 weeks. Mechanical hyperalgesia was measured using von Frey filament test. The paw withdrawal threshold (PWT) of the vehicle treated group (n = 10) progressively decreased throughout the 12 weeks, and were lower than SR9009 treated group (n = 10) at all time points after 6 weeks. (Fig. 2B) Heat hyperalgesia was measured using hot-plate test. The paw thermal threshold (PTT) in the vehicle treated group was reduced as compared with the SR9009 treated group after 6 weeks (n = 10 per group). Values are mean±SEM.