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. Author manuscript; available in PMC: 2021 Apr 29.
Published in final edited form as: Gene. 2018 Feb 20;655:1–12. doi: 10.1016/j.gene.2018.02.048

Figure 7: Analgesic activity of the i.a. REV-ERB agonist SR9009 in a model of OA (osteoarthritis) induced pain.

Figure 7:

Expression of pain-related targets in the dorsal root ganglia (DRG) following groups of mice including naïve, PMM and SR9009 treated mice. Double immunofluorescence staining of TrkA (red; 7A-7C), NGF (red; 7D-7F), Nav1.7 (red; 7G-7I), Nav1.8 (red; 7J-7L) and TRPV1 (red; 7M-7O) and NeuN (green) in DRGs of Naïve, PMM and SR9009 treated groups mice. Co-localization of the two stains appears yellow. A scale bar was 20μm and is shown in white in color for all images. Quantitative analyses of TrkA, NGF, Nav1.7, Nav1.8 and TRPV1expression in DRGs (Fig. 7P-7T) showed that they were increased in OA mice, but that was reduced with i.a. SR9009. Values are mean±SEM.