Figure 5.

TCE alters the levels of mediators of bone remodeling. Spleen adherent cells (SAC) (a) and synovial-infiltrating cells (SIC) (b) were harvested from arthritic Lewis rats fed either with TCE or with water, on day 19 after Mtb challenge. The SIC and SAC were then restimulated for 24 h with Mtb sonicate (10 ug/mL) (n = 3 each). The mRNA expression of the bone remodeling-related mediators in these cells was quantified by qRT-PCR and the results were expressed as “fold over medium” after normalization to HPRT (*, P <0.05, when comparing TCE and control samples).