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. 2020 Dec 18;320(2):H772–H786. doi: 10.1152/ajpheart.00606.2020

Figure 2.

Figure 2.

Representative tracings (A, B) and grouped data (C) showing the effects of intracarotid artery (ICA) injection of tumor necrosis factor (TNF)-α on blood pressure (BP, mmHg), heart rate (HR, bpm), and renal sympathetic nerve activity (RSNA), windowed (spikes/s) and integrated (mV), in rats receiving a continuous intracerebroventricular (ICV) infusion of vehicle (VEH) (A) or AG1478 (B). Arrows indicate the timing of the injections. Scale bar: 30 min. MBP, mean blood pressure; ΔRSNA (%), percent change from baseline in integrated RSNA. All values are expressed as the means ± SE (in C, n = 6 for each group). *P < 0.05 compared with baseline. †P < 0.05 compared with ICA TNF-α in ICV VEH-pretreated rats.