Table 4.
Levels of associations between MetaCyc pathways and markers
| Metabolic pathway | Changea | RMC | LME | Pathway | |
|---|---|---|---|---|---|
| ZON | CALP | ||||
| P-163 PWY | Same | L-lysine fermentation to acetate and butanoate | |||
| CENTFERM-PWY | Same | Calp (common slope model, negative β coeff.) | Pyruvate fermentation to butanoate | ||
| FUCCAT-PWY | Same | Zon ( +) | Fucose degradation | ||
| GLCMANNANAUT-PWY | Same | Superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation | |||
| PWY-4984 | Same | Urea cycle | |||
| PWY-6588 | Same |
Zon (+), Calp (−) |
Pyruvate fermentation to acetone | ||
| PWY-6590 | Same | Calp (common slope model, negative β coeff.) | Superpathway of Clostridium acetobutylicum acidogenic fermentation | ||
| PWY-6608 | Same | Guanosine nucleotides degradation III | |||
| PWY-7003 | Same | Zon (+) | Glycerol degradation to butanol | ||
| PWY-7013 | Same | (S)-propane-1,2-diol degradation | |||
| PWY-7184 | Opposite | Pyrimidine deoxyribonucleotides de novo biosynthesis I | |||
| PWY-7237 | Same | Zon (+) | myo-, chiro- and scyllo-inositol degradation | ||
| FUC-RHAMCAT-PWY | Zon (+) | Superpathway of fucose and rhamnose degradation | |||
| PWY-5676 | Zon (+) | Acetyl-CoA fermentation to butanoate II | |||
| PWY-5677 |
Zon (+), Calp (−) |
Succinate fermentation to butanoate | |||
| PWY-6353 | Zon (+) | Purine nucleotides degradation II (aerobic) | |||
| PWY-6478 | Zon (+) | GDP-D-glycero-alpha-D-manno-heptose biosynthesis | |||
| PENTOSE-P-PWY | Calp (common slope model, positive β coeff.) | Pentose phosphate pathway | |||
| PWY-6545 |
Zon (different slopes model) negative β coeff.: P3-P4; positive β coeff.: P4–P6, P5–P6 |
Pyrimidine deoxyribonucleotides de novo biosynthesis III | |||
| PWY0-845 | Zon (different slopes model) positive β coeff.: P3–P4 | Superpathway of pyridoxal 5′-phosphate biosynthesis and salvage | |||
| PWY-6901 | Zon (different slopes model) positive β coeff.: P3–P4, P5–P6 | Superpathway of glucose and xylose degradation | |||
| SALVADEHYPOX-PWY | Zon (+) | Adenosine nucleotides degradation II | |||
aco-occurrence between change in the pathway abundance and change in zonulin (P2-P4/P5/P6, P3-P4/P5/P6) or calprotectin (P2-P5/P6, P3-P5/P6, P4-P6) levels: same—a change in the pathway abundance and change in marker level between time points occur in the same direction, opposite—a change in the pathway abundance and change in marker level between time points occur in the opposite direction. RMC (repeated measures correlation)—correlation between the pathway abundance and concentration of zonulin/calprotectin for paired measures assessed on six occasions (from P1 to P6, i.e., the entire observation period); LME (linear mixed-effects analysis)—an association between the pathway abundance change and marker change accounting for multiple time point pairs from the same subject, including time-point pair-specific relationships with either absence (the common slope model) or presence of the interaction (the different slopes model) between the abundance change and the time point pair); (+), positive RMC coefficient; (−), negative RMC coefficient