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. 2021 Apr 29;13:50. doi: 10.1186/s13098-021-00664-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Knockdown of miR-149 partly reversed the biological effects of hesperidin. a The transfection efficiency of the miR-149 inhibitor was detected by qRT-PCR. b The effect of miR-149 downregulation on hesperidin-mediated ROS production was detected by a fluorescent MitoSox probe. c The effect of miR-149 downregulation on the hesperidin-regulated MMP level was determined by JC-1 staining. d, e The effects of miR-149 downregulation on hesperidin-regulated ATP and glucose contents were quantified by corresponding detection kits. f The effects of miR-149 downregulation on hesperidin-mediated phosphorylation of GSK3β, AKT and IRS1 were quantified by western blotting. All the data were presented as the mean ± S.D. *p < 0.05, **p < 0.01, *** p < 0.001