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. 2021 Apr 28;22:308. doi: 10.1186/s12864-021-07606-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — PANTHER GO Molecular Functions found to be overrepresented by differentially regulated proteins. Panel a. vtg1-KO Experiment. Panel b. vtg3-KO Experiment. Only proteins that were identified in > 4 biological samples and that exhibited a > 1.5-fold difference in N-SC between groups (vtg3-KO versus Wt), or proteins unique to a certain group, were included in this analysis. Horizontal bars indicate the number of proteins attributed to each GO term for which statistically significant results (Fisher’s Exact test, p < 0.05, followed by Bonferroni correction for multiple testing (p < 0.05)) were observed. Numbers next to the bars indicate the fold-enrichment with proteins attributed to each term and the number of asterisks indicates the significance level of the enrichment, as follows p < 0.05 (*), p < 0.01 (**), p < 0.001 (***), and p < 0.0001 (****). Where possible, horizontal bars are colored to indicate corresponding protein functional categories shown in Fig. 1; lipid metabolism (yellow), cell cycle, division, growth and fate (lavender), protein degradation and synthesis inhibition (dark blue)