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. 2021 Apr 28;14:59. doi: 10.1186/s13048-021-00814-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Plasma derived exosomal miR-4732-5p as a diagnostic biomarker. SYBER green quantitative RT-PCR indicated that miR-4732-5p (a) was significantly up-regulated in ovarian cancer patient plasma derived exosomes when compared with healthy controls (p = 0.003),while there was no significant changed for miR-1273f (b). c Plasma derived exosomal miR-4732-5p was significantly up-regulated in late-stage ovarian cancer patient when compared with early-stage group (p = 0.016). d ROC curve analysis indicated that the AUC of miR-4732-5p between ovarian cancer patients and healthy controls was 0.889 (p<0.0001). e The correlation between CA-125 level and miR-4732-5p