Table 2.

Select cell death inhibitors that were combined with QD394 in pancreatic cancer cells.

Cell death	Target	Inhibitor
Apoptosis	All caspases	Z-VAD-FMK
Necroptosis	RIP1 kinase	Necrostatin-1
	Selective inhibitor of RIP1	Necrostatin-1s
Ferroptosis	Iron; iron-dependent prolyl hydroxylases; lysosomal ROS inhibitor by chelating lysosomal redox-active iron	Deferoxamine (DFO), deferasirox
	Inhibit autooxidation of lipids by trapping peroxyl radicals; not rescue H2O2-induced cell death	Ferrostatin-1
	Inhibit ferroptosis induced by L-buthionine sulphoximine (BSO), erastin and (1S,3R)-RSL3; inhibit autooxidation of lipids by trapping peroxyl radicals	Liproxstatin-1
Autophagy	Impair autophagosome fusion with lysosomes	Chloroquine
	Inhibit PI3K activity and the initial phase of the autophagic process	3-Methyladenine
Parthanatos	PARP inhibitors	Olaparib
	AIF release inhibitors	N-phenylmaleimide