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. 2021 Apr 15;11:611544. doi: 10.3389/fonc.2021.611544

Figure 2.

Figure 2

Bioinformatics analysis of a correlation between an elevated WTAP expression and a poor survival of the patients with HCC in public databases. (A) Quantification of WTAP messenger RNA (mRNA) expression levels in patients with HCC in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data sets. (B) WTAP mRNA expression levels in HCC tissues with different Tumor-Node-Metastasis (TNM) stages based on a TCGA HCC cohort analysis. (C,D) A prognostic significance of the WTAP expression in patients with HCC was analyzed in the TCGA (n = 367) database. (E,F) A prognostic significance of the WTAP expression in patients with HCC at different TNM stages was analyzed in the TCGA (n = 367) database. (G) Pearson correlation analysis of WTAP expression levels with the Ki-67 or proliferating cell nuclear antigen (PCNA) expression in TCGA HCC data sets. (H) Gene set enrichment analysis (GSEA) of a correlation between the WTAP expression and gene signatures of the survival in HCC. *p < 0.05, **p < 0.01 based on the non-parametric test.