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. 2021 Apr 15;11:611544. doi: 10.3389/fonc.2021.611544

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Copyright © 2021 Liu, Gao, Chen, Zhao, Sun, Zou, Guan, Yang, Pei, Wang, Wang, Li and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of WTAP suppresses the HCC tumorigenesis in vivo SMMC-7721 cells stably transfected with a sh-WTAP or negative control (NC) were subcutaneously implanted into nude mice, and the tumor growth was monitored. (A) Representative photos of nude mice and HCC tumor tissues from the control (Ctrl) or sh-WTAP group at week 5. (B) Tumor volume was monitored and calculated at the indicated time points. (C) Tumor weight of tumors from the Ctrl or sh-WTAP group were analyzed; n = 5 per group. (D) Representative IHC staining and the expression levels of WTAP or Ki-67 in the tumor tissues from the Ctrl or sh-WTAP group. *p < 0.05, **p < 0.01.