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. Author manuscript; available in PMC: 2021 Apr 29.
Published in final edited form as: J Med Chem. 2021 Jan 28;64(3):1626–1648. doi: 10.1021/acs.jmedchem.0c01897

Figure 10.

Figure 10.

NQO1-induced cytotoxicity of XD2–149 is independent of ZFP91. (A) Dicoumarol partially rescues the cell death caused by XD2–149 in CFA. BxPC-3 and MIA PaCa-2 cells were treated with XD2–149 or napabucsain for 7–10 days. (B) Dicoumarol (DIC) effect is independent of ZFP91. BxPC-3 cells were treated with XD2–149 in absence or presence of DIC for 16 h. The proteasome inhibitor carfilzomib was added 1 h prior to the treatments.