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. Author manuscript; available in PMC: 2021 Apr 29.
Published in final edited form as: J Med Chem. 2021 Jan 28;64(3):1626–1648. doi: 10.1021/acs.jmedchem.0c01897

Scheme 3. Synthesis of Compound 4–5a.

Scheme 3.

aReagents and conditions: (a) NaOAc, HOAc, 120 °C; (b) Pd(PPh3)2Cl2, CuI, TEA, DMF, 80 °C; (c) TFA, DCM, rt; (d) HATU, DIPEA, DMF, rt.