Table 3.

Downregulated Proteins Exclusive to XD2–149 Treatment in BxPC-3 Cells

No	Gene Symbol	Name	Log2FCa	p-valueb
1	TMPRSS4	Transmembrane protease serine 4	−1.27	0.028
2	PLK1	Serine/threonine-protein kinase PLK1	−1.25	0.020
3	TP53BP2	Apoptosis-stimulating of p53 protein 2	−1.02	0.005
4	DYNLT1	Dynein light chain Tctex-type 1	−0.97	0.014
5	DTX3L	E3 ubiquitin-protein ligase DTX3L	−0.96	0.042
6	MAGED1	Melanoma-associated antigen D1	−0.9	0.002
7	STAT2	Signal transducer and activator of transcription 2	−0.9	0.010
8	CBR1; SETD4	Carbonyl reductase [NADPH] 1	−0.86	<0.001
9	SPINT1	Kunitz-type protease inhibitor 1	−0.85	0.001
10	CCNB1	G2/mitotic-specific cyclin-B1	−0.84	0.031
11	EDF1	Endothelial differentiation-related factor 1	−0.82	<0.001
12	CST3	Cystatin-C	−0.81	0.001
13	NABP2	SOSS complex subunit B1	−0.78	0.008
14	WDFY4	WD repeat- and FYVE domain-containing protein 4	−0.78	0.009
15	CSDE1	Cold shock domain-containing protein E1	−0.75	<0.001
16	SHPRH	E3 ubiquitin-protein ligase SHPRH	−0.74	0.007
17	FAM3C; WNT16	Protein FAM3C	−0.73	<0.001
18	DDR1	Epithelial discoidin domain-containing receptor 1	−0.73	<0.001
19	DSP	Desmoplakin	−0.70	0.002
20	GPR56; ADGRG1	Adhesion G-protein coupled receptor G1	−0.69	0.004
21	STAT3	Signal transducer and activator of transcription 3	−0.69	0.001
22	LTV1	Protein LTV1 homolog	−0.69	0.003
23	AGRN	Agrin	−0.68	0.001
24	SDF4	45 kDa calcium-binding protein	−0.67	0.002
25	LAMB1	Laminin subunit beta-1	−0.67	<0.001
26	UBE2T	Ubiquitin-conjugating enzyme E2 T	−0.66	0.029
27	PHLDB1	Pleckstrin homology-like domain family B member 1	−0.64	0.009
28	CHST14	Carbohydrate sulfotransferase 14	−0.64	0.001
29	PLOD2	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	−0.63	0.019
30	PVRL1; NECTIN1	Nectin-1	−0.63	0.002
31	PRRC2B	Protein PRRC2B	−0.63	0.003
32	MGMT	Methylated-DNA--protein-cysteine methyltransferase	−0.63	0.004
33	NSMCE2	E3 SUMO-protein ligase NSE2	−0.63	0.012
34	ZFP91	E3 ubiquitin-protein ligase ZFP91	−0.62	0.002
35	SERF2	Small EDRK-rich factor 2	−0.61	0.002
36	POLD4	DNA polymerase delta subunit 4	−0.61	0.017
37	PRDM16	Histone-lysine N-methyltransferase PRDM16	−0.6	0.033
38	CIAPIN1	Anamorsin	−0.59	<0.001
39	CCNDBP1	Cyclin-D1-binding protein 1	−0.59	0.005
40	USP8	Ubiquitin carboxyl-terminal hydrolase 8	−0.59	0.008

^aFC > 1.5.

^bp-value ≤ 0.05.